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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8932590 B1

PDFFull Text
Date of Patent:
Jan. 13, 2015

Filed:

Jun. 15, 2011

Method of adsorbing transforming growth factor β

Applicants:

Kazuo Teramoto, Otsu, JP;

Toshio Yoshioka, Otsu, JP;

Masaaki Shimagaki, Otsu, JP;

Takeo Matsunase, Moriyama, JP;

Koji Watanabe, Kusatsu, JP;

Yuji Ueda, Kyoto, JP;

Yoshiki Yamamoto, Kyoto, JP;

Inventors:

Kazuo Teramoto, Otsu, JP;

Toshio Yoshioka, Otsu, JP;

Masaaki Shimagaki, Otsu, JP;

Takeo Matsunase, Moriyama, JP;

Koji Watanabe, Kusatsu, JP;

Yuji Ueda, Kyoto, JP;

Yoshiki Yamamoto, Kyoto, JP;

Assignee:

TORAY Industries, Inc., Tokyo, JP;

Attorney:

Kubovcik & Kubovcik

Primary Examiner:

James Rogers

Int. Cl.
CPC ...
A61K 39/395 (2006.01); B01J 20/26 (2006.01); B01J 20/28 (2006.01); B01J 20/32 (2006.01); B01J 20/30 (2006.01); A61M 1/36 (2006.01);
U.S. Cl.
CPC ...
B01J 20/26 (2013.01); B01J 20/28023 (2013.01); B01J 20/2803 (2013.01); B01J 20/28033 (2013.01); B01J 20/3242 (2013.01); B01J 20/28014 (2013.01); B01J 20/261 (2013.01); B01J 20/262 (2013.01); B01J 20/265 (2013.01); B01J 20/321 (2013.01); B01J 20/3212 (2013.01); B01J 20/3217 (2013.01); B01J 20/3251 (2013.01); B01J 20/3272 (2013.01); B01J 20/3293 (2013.01); B01J 20/3092 (2013.01); B01J 20/28057 (2013.01); B01J 20/28045 (2013.01); B01J 20/28016 (2013.01); A61M 1/3679 (2013.01); B01J 2220/58 (2013.01); B01J 2220/60 (2013.01);
Abstract

An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor β which is combined with another protein, includes adsorbing the transforming growth factor β and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.1 mor more per gram.

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