logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8932589 B1

PDFFull Text
Date of Patent:
Jan. 13, 2015

Filed:

Mar. 12, 2013

Methods and compositions using kloto-fgf23 fusion polypeptides

Applicants:

David Glass, Cortland Manor, NY (US);

Shou-ih HU, New Providence, NJ (US);

Inventors:

David Glass, Cortland Manor, NY (US);

Shou-Ih Hu, New Providence, NJ (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:

Frank Wu

Primary Examiner:

Christine J Saoud

Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 39/395 (2006.01); C07K 14/50 (2006.01); C07K 16/00 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C12N 15/63 (2006.01); C12N 9/42 (2006.01); C12N 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/50 (2013.01); C12Y 302/01021 (2013.01); C12N 9/2445 (2013.01); C12Y 302/00 (2013.01); C12Y 602/01003 (2013.01); C12N 9/93 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment.

Find Patent Forward Citations

Loading…