Preparative separation/purification system

Abstract

The present invention aims at providing a preparative separation/purification system for vaporizing an eluate in a short period of time, while enhancing the efficiency of collecting the target substance by accelerating the initiation of collecting the eluate. The preparative separation/purification system in which water containing a target component is passed through a columnto capture the target component in the columnand then a solvent is passed through it to collect the target compound, includes: a liquid supply meansfor supplying a solvent to the column, with the target component captured in the column, while the columnis vertically held with the inlet end thereof directed downwards and the discharge end thereof directed upwards, the solvent having a low solubility to water and having a specific gravity greater than that of water; a passage selection meansfor changing the passage configuration so that a solution exiting from the columnis selectively sent to either a collection passageor a disposal passage; a passage control meansfor controlling the passage selection meansso that, when water exits from the column, the water is sent to the disposal passage, and when solution containing solvent exits from the column, the solution is sent to the collection passage; and a flow rate control meansfor controlling so that the water is supplied at a first flow rate to the disposal passage, and the solution containing solvent is supplied to the collection passageat a flow rate lower than the first flow rate.