The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2015

Filed:

Feb. 28, 2013
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

John Q. Trojanowski, Philadelphia, PA (US);

Virginia M. Y. Lee, Philadelphia, PA (US);

Kurt R. Brunden, Media, PA (US);

Amos B. Smith, Merion, PA (US);

Donna M. Huym, Allentown, NJ (US);

Carlo Ballatore, Philadelphia, PA (US);

Anne-Marie Hogan, Mount Merrion, IE;

Francesco Piscitelli, Marina di Strongoll, IT;

Sugiyama Shimpei, Shizuoka, JP;

Xiaozhao Wang, Drexel Hill, PA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 311/20 (2006.01); C07D 317/28 (2006.01); A61K 31/18 (2006.01); A61K 31/196 (2006.01); A61K 31/216 (2006.01); A61K 31/357 (2006.01); A61K 31/41 (2006.01); A61K 31/4174 (2006.01); A61K 31/421 (2006.01); A61K 31/426 (2006.01); A61K 45/06 (2006.01); C07D 233/64 (2006.01); C07D 257/04 (2006.01); C07D 263/32 (2006.01); C07D 277/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/18 (2013.01); A61K 31/196 (2013.01); A61K 31/216 (2013.01); A61K 31/357 (2013.01); A61K 31/41 (2013.01); A61K 31/4174 (2013.01); A61K 31/421 (2013.01); A61K 31/426 (2013.01); A61K 45/06 (2013.01); C07C 311/20 (2013.01); C07D 233/64 (2013.01); C07D 257/04 (2013.01); C07D 263/32 (2013.01); C07D 277/28 (2013.01); C07D 317/28 (2013.01);
Abstract

The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to activation of TP receptor utilizing the compounds of the invention.


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