The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Mar. 30, 2010
Lixin Qiao, Tewksbury, MA (US);
Marcie Glicksman, Winchester, MA (US);
Thomas Gainer, Swampscott, MA (US);
Donald C. Lo, Chapel Hill, NC (US);
Ross L. Stein, Cambridge, MA (US);
Sungwoon Choi, Sharon, MA (US);
Gregory D. Cuny, Somerville, MA (US);
Lixin Qiao, Tewksbury, MA (US);
Marcie Glicksman, Winchester, MA (US);
Thomas Gainer, Swampscott, MA (US);
Donald C. Lo, Chapel Hill, NC (US);
Ross L. Stein, Cambridge, MA (US);
Sungwoon Choi, Sharon, MA (US);
Gregory D. Cuny, Somerville, MA (US);
Duke University, Durham, NC (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.