The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Feb. 02, 2009
Applicant:
Sylvestre Grizot, La Garenne Colombes, FR;
Inventor:
Sylvestre Grizot, La Garenne Colombes, FR;
Assignee:
Cellectis, S.A., Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); C07K 14/00 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C07K 2319/00 (2013.01);
Abstract
A new I-CreI derived single-chain meganuclease comprising two domains, each domain comprising a portion of a parent I-CreI monomer which extends at least from the beginning of the first alpha helix to the end of the C-terminal loop and said two domains being joined by a peptidic linker which allows them to fold as a I-CreI dimer that is able to bind and cleave a chimeric DNA target comprising one different half of each parent homodimeric I-CreI meganuclease target sequence. Use of said I-CreI derived single-chain meganuclease for genetic engineering, genome therapy and antiviral therapy.