The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Mar. 01, 2008
Yoshihiko Hamamoto, Ube, JP;
Norio Iizuka, Ube, JP;
Toshiaki Miura, Tokyo, JP;
Toyoki Moribe, Tokyo, JP;
Masaaki Oka, Ube, JP;
Shigeru Tamatsukuri, Tokyo, JP;
Yoshihiko Hamamoto, Ube, JP;
Norio Iizuka, Ube, JP;
Toshiaki Miura, Tokyo, JP;
Toyoki Moribe, Tokyo, JP;
Masaaki Oka, Ube, JP;
Shigeru Tamatsukuri, Tokyo, JP;
Roche Molecular Systems, Inc., Pleasanton, CA (US);
Abstract
The present invention provides a novel method for detection of liver cancer. This method detects high-sensitively, high-specifically, simply and accurately liver cancer, especially that in early stage by identifying and/or quantifying methylation on particular genes and/or their DNA fragments in clinical specimens, and by combining said methylated DNA values with existing tumor marker values and/or DNA amounts in blood. This invention also detects a precancerous lesion, detects a risk of recurrence after treatment of liver cancer, detects malignancy of liver cancer and monitors progression of liver cancer with time by the same method. As for particular genes, BASP1 gene, SPINT2 gene, APC gene, CCND2 gene, CFTR gene, RASSF1 gene and SRD5A2 gene are mentioned.