The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Mar. 24, 2005
Klaus Pfizenmaier, Tiefenbronn, DE;
Peter Scheurich, Stuttgart, DE;
Ingo Grunwald, Bremen, DE;
Anja Krippner-heidenreich, Newcastle upon Tyne, GB;
Klaus Pfizenmaier, Tiefenbronn, DE;
Peter Scheurich, Stuttgart, DE;
Ingo Grunwald, Bremen, DE;
Anja Krippner-Heidenreich, Newcastle upon Tyne, GB;
Universitat of Stuttgart, Stuttgart, DE;
Abstract
The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.