The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Apr. 05, 2005
Prediman K. Shah, Los Angeles, CA (US);
Saswati Chatterjee, Sierra Madre, CA (US);
Kamehameha Kay-min Wong, Jr., Sierra Madre, CA (US);
Prediman K. Shah, Los Angeles, CA (US);
Saswati Chatterjee, Sierra Madre, CA (US);
Kamehameha Kay-Min Wong, Jr., Sierra Madre, CA (US);
Cedars-Sinai Medical Center, Los Angeles, CA (US);
City of Hope, Duarte, CA (US);
Abstract
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery.