The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2015

Filed:

Apr. 09, 2010
Applicants:

Rafael Davalos, Blacksburg, VA (US);

Christopher B. Arena, Denver, NC (US);

John Caldwell, Blacksburg, VA (US);

Inventors:

Rafael Davalos, Blacksburg, VA (US);

Christopher B. Arena, Denver, NC (US);

John Caldwell, Blacksburg, VA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 18/04 (2006.01); A61N 1/32 (2006.01); A61B 18/14 (2006.01); A61N 1/04 (2006.01); A61B 18/00 (2006.01);
U.S. Cl.
CPC ...
A61N 1/327 (2013.01); A61B 18/1477 (2013.01); A61N 1/0412 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/0016 (2013.01); A61N 1/0424 (2013.01);
Abstract

The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.


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