The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
Jun. 05, 2013
Unither Virology, Llc, Washington, DC (US);
The Chancellor, Masters and Scholars of the University of Oxford, Oxford, GB;
J. L. Kiappes, Oxford, GB;
Peter Laing, Willingham, GB;
Raymond Dwek, Oxfordshire, GB;
Nicole Zitzmann, Oxfordshire, GB;
Stephanie Pollock, Oxfordshire, GB;
Unither Virology, LLC, Silver Spring, MD (US);
The Chancellor, Masters and Scholars of The University of Oxford, Oxford, GB;
Abstract
Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogs of tocopherol or select analogs of cholesterol, or its antagonist 'Ezitimibe'; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.