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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8921563 B1

PDFFull Text
Date of Patent:
Dec. 30, 2014

Filed:

Apr. 08, 2011

1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1h)-one derivatives, preparation methods and uses thereof

Applicants:

Yunfeng LI, Beijing, CN;

Rifang Yang, Beijing, CN;

Youzhi Zhang, Beijing, CN;

Yongzhen LI, Beijing, CN;

Zengliang Jin, Beijing, CN;

Peng LI, Beijing, CN;

LI Yuan, Beijing, CN;

Liuhong Yun, Beijing, CN;

Nan Zhao, Beijing, CN;

Cheng Zhang, Beijing, CN;

Xiaodan Xu, Beijing, CN;

Rusheng Zhao, Beijing, CN;

Hongxia Chen, Beijing, CN;

Rui Xue, Beijing, CN;

Juanjuan Qin, Beijing, CN;

Zhenzhen Wang, Beijing, CN;

Jiazhi Yao, Beijing, CN;

Inventors:

Yunfeng Li, Beijing, CN;

Rifang Yang, Beijing, CN;

Youzhi Zhang, Beijing, CN;

Yongzhen Li, Beijing, CN;

Zengliang Jin, Beijing, CN;

Peng Li, Beijing, CN;

Li Yuan, Beijing, CN;

Liuhong Yun, Beijing, CN;

Nan Zhao, Beijing, CN;

Cheng Zhang, Beijing, CN;

Xiaodan Xu, Beijing, CN;

Rusheng Zhao, Beijing, CN;

Hongxia Chen, Beijing, CN;

Rui Xue, Beijing, CN;

Juanjuan Qin, Beijing, CN;

Zhenzhen Wang, Beijing, CN;

Jiazhi Yao, Beijing, CN;

Assignee:

Institue of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A., China, Beijing, CN;

Attorney:

Brinks Gilson & Lione

Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
A61K 31/445 (2006.01); A61K 31/505 (2006.01); C07D 211/68 (2006.01); C07D 239/02 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01);
Abstract

Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof. The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.

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