The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Nov. 30, 2011
Applicants:

James C. Lanter, Spring House, PA (US);

Thomas P. Markotan, Morgantown, PA (US);

Nalin Subasinghe, Exton, PA (US);

Zhihua Sui, Spring House, PA (US);

Xuqing Zhang, Spring House, PA (US);

Inventors:

James C. Lanter, Spring House, PA (US);

Thomas P. Markotan, Morgantown, PA (US);

Nalin Subasinghe, Exton, PA (US);

Zhihua Sui, Spring House, PA (US);

Xuqing Zhang, Spring House, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 401/12 (2006.01); A61K 31/437 (2006.01); A61K 31/4545 (2006.01); A61K 31/454 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 471/04 (2013.01); C07D 405/14 (2013.01);
Abstract

The present invention comprises compounds of Formula (I). wherein: R, R, R, R, X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).


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