The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
Mar. 12, 2014
Applicant:
Abbvie Inc., North Chicago, IL (US);
Inventors:
Chris M. Chumsae, North Andover, MA (US);
Zehra Kaymakcalan, Westborough, MA (US);
Assignee:
AbbVie, Inc., North Chicago, IL (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/18 (2006.01); A61K 39/395 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); C07K 2317/40 (2013.01); Y10S 514/863 (2013.01);
Abstract
The present invention is directed to modified antibodies, including anti-TNFα antibodies, in which C-terminal amino acids of heavy chain sequences are modified from a native sequence of proline-glycine-lysine ('PGK') to one that includes a proline positioned between the glycine and lysine, resulting in a C-terminal sequence of proline-glycine-proline-lycine ('PGPK'). The invention further provides methods of producing and using such antibodies.