The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Oct. 17, 2007
Applicants:

Gerhard Zoller, Frankfurt am Main, DE;

Stefan Petry, Frankfurt am Main, DE;

Gunter Muller, Frankfurt am Main, DE;

Hubert Heuer, Frankfurt am Main, DE;

Norbert Tennagels, Frankfurt am Main, DE;

Inventors:

Gerhard Zoller, Frankfurt am Main, DE;

Stefan Petry, Frankfurt am Main, DE;

Gunter Muller, Frankfurt am Main, DE;

Hubert Heuer, Frankfurt am Main, DE;

Norbert Tennagels, Frankfurt am Main, DE;

Assignee:

Sanofi, Paris, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4523 (2006.01); A61K 31/423 (2006.01); A61K 31/428 (2006.01); C07D 275/04 (2006.01); C07D 498/04 (2006.01); C07D 261/20 (2006.01); C07D 413/12 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 261/20 (2013.01); C07D 275/04 (2013.01); C07D 413/12 (2013.01); C07D 513/04 (2013.01);
Abstract

The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their inhibitory effect on hormone sensitive lipase, HSL, an allosteric enzyme in adipocytes which is inhibited by insulin and is responsible for the breakdown of fats in fat cells and thus for transferring fat constituents into the blood stream. Inhibition of this enzyme is therefore equivalent to an insulin-like effect of the compounds of the invention.


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