The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Mar. 19, 2014
Applicants:

Sabine Axt, Sunnyvale, CA (US);

Timothy J. Church, San Mateo, CA (US);

Inventors:

Sabine Axt, Sunnyvale, CA (US);

Timothy J. Church, San Mateo, CA (US);

Assignee:

Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4545 (2006.01); C07D 211/30 (2006.01); C07D 401/12 (2006.01); A61K 45/06 (2006.01); A61M 15/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 45/06 (2013.01); A61K 31/4545 (2013.01); A61M 15/00 (2013.01);
Abstract

The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and pharmaceutically acceptable solvates thereof. The crystalline form can be a freebase, or a salt such as a diphosphate, monosulfate or dioxalate salt. The invention also provides pharmaceutical compositions comprising these crystalline compounds or prepared using these compounds; processes and intermediates for preparing the crystalline compounds; and methods of using these compounds to treat a pulmonary disorder.


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