The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Apr. 20, 2012
Applicants:

Olli Törmäkangas, Turku, FI;

Gerd Wohlfahrt, Helsinki, FI;

Harri Salo, Turku, FI;

Rathna Durga Ramasubramanian, Turku, FI;

Pranab Kumar Patra, Noida, IN;

Arputharaj Ebenezer Martin, Noida, IN;

Terhi Heikkinen, Lieto, FI;

Anniina Vesalainen, Paimio, FI;

Anu Moilanen, Turku, FI;

Arja Karjalainen, Espoo, FI;

Inventors:

Olli Törmäkangas, Turku, FI;

Gerd Wohlfahrt, Helsinki, FI;

Harri Salo, Turku, FI;

Rathna Durga Ramasubramanian, Turku, FI;

Pranab Kumar Patra, Noida, IN;

Arputharaj Ebenezer Martin, Noida, IN;

Terhi Heikkinen, Lieto, FI;

Anniina Vesalainen, Paimio, FI;

Anu Moilanen, Turku, FI;

Arja Karjalainen, Espoo, FI;

Assignee:

Orion Corporation, Espoo, FI;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 231/14 (2006.01); C07D 487/04 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 401/04 (2006.01); C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 231/14 (2013.01); C07D 403/04 (2013.01); C07D 471/04 (2013.01); C07D 403/14 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 401/04 (2013.01); C07D 413/14 (2013.01); C07D 413/12 (2013.01); C07D 513/04 (2013.01);
Abstract

Compounds of formula (I) or (II) wherein R, R, R, R, R, R', R, R′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.


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