The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
May. 20, 2010
Nicolas Fischer, Geneva, CH;
Marie Kosco-vilbois, Minzier, FR;
Ulla Ravn, Geneva, CH;
Franck Gueneau, Saint-Julien-en-Genevois, FR;
Sophie Venet-bonnot, Saint-Julien-en-Genevois, FR;
Nicolas Fischer, Geneva, CH;
Marie Kosco-Vilbois, Minzier, FR;
Ulla Ravn, Geneva, CH;
Franck Gueneau, Saint-Julien-en-Genevois, FR;
Sophie Venet-Bonnot, Saint-Julien-en-Genevois, FR;
NovImmune S.A., Geneva, CH;
Abstract
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.