The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Sep. 19, 2006
Applicants:

R. Lane Smith, Palo Alto, CA (US);

Laurence J. B. Tarrant, Northampton, MA (US);

Akihiko Kusanagi, Brookline, MA (US);

Hans Peter Ingemar Claesson, Wayland, MA (US);

Inventors:

R. Lane Smith, Palo Alto, CA (US);

Laurence J. B. Tarrant, Northampton, MA (US);

Akihiko Kusanagi, Brookline, MA (US);

Hans Peter Ingemar Claesson, Wayland, MA (US);

Assignee:

Histogenics Corporation, Waltham, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61L 27/38 (2006.01); A61L 27/24 (2006.01); A61L 27/56 (2006.01); C12N 5/077 (2010.01); C12N 5/07 (2010.01); A61F 2/30 (2006.01); A61F 2/08 (2006.01); A61F 2/38 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3843 (2013.01); A61L 27/24 (2013.01); A61L 27/3817 (2013.01); A61L 27/56 (2013.01); C12N 5/0655 (2013.01); A61F 2/08 (2013.01); A61F 2/30756 (2013.01); A61F 2/3872 (2013.01); A61F 2002/30062 (2013.01); A61F 2210/0004 (2013.01); A61F 2310/00365 (2013.01); C12N 2533/54 (2013.01);
Abstract

A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.


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