The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
Nov. 22, 2010
Yong Gan, Shanghai, CN;
Chunliu Zhu, Shanghai, CN;
Qingmin Yang, Jinan, CN;
Jingyi Wang, Jinan, CN;
Xiaoqing Zheng, Jinan, CN;
LI Gan, Shanghai, CN;
Xinxin Zhang, Shanghai, CN;
Yong Gan, Shanghai, CN;
Chunliu Zhu, Shanghai, CN;
Qingmin Yang, Jinan, CN;
Jingyi Wang, Jinan, CN;
Xiaoqing Zheng, Jinan, CN;
Li Gan, Shanghai, CN;
Xinxin Zhang, Shanghai, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
QILU Pharamceutical Co., Ltd., Shandong, CN;
Abstract
A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.