The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2014

Filed:

Mar. 03, 2014
Applicants:

Paladin Labs Inc., Montreal, CA;

Paladin Labs (Barbados) Inc., Hastings, Christ Church, BB;

Paladin Labs Europe Limited, Dublin, IE;

Inventors:

Miloud Rahmouni, Pierrefonds, CA;

Angela Ferrada, Montreal, CA;

Fouzia Soulhi, Dollar-Des-Ormeaux, CA;

Sonia Gervais, Laval, CA;

Vinayak Sant, Pittsburgh, PA (US);

Damon Smith, Saint-Laurent, CA;

Frederic Duffayet, Montreal, CA;

Shams Rustom, Saint-Laurent, CA;

Ali El-Jammal, Beaconsfield, CA;

Jean-Michel Ndong, Repentigny, CA;

Bobby-Ernst Boursiquot, Laval, CA;

Ali Bichara, Ste-Therese, CA;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 9/24 (2006.01); A61K 9/14 (2006.01); A61K 31/00 (2006.01); A61K 9/50 (2006.01); A61K 31/135 (2006.01);
U.S. Cl.
CPC ...
A61K 9/2027 (2013.01); A61K 9/2866 (2013.01); A61K 9/209 (2013.01); A61K 9/14 (2013.01); A61K 9/2054 (2013.01); A61K 9/284 (2013.01); A61K 31/00 (2013.01); A61K 9/286 (2013.01); A61K 9/20 (2013.01); A61K 9/28 (2013.01); A61K 9/50 (2013.01); A61K 9/205 (2013.01); A61K 31/135 (2013.01); A61K 9/2846 (2013.01); A61K 9/2031 (2013.01);
Abstract

Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the coreswells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof.


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