The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
Feb. 01, 2012
Dong Won Lee, Jeonbuk, KR;
Kyeong Yeol Seong, Jeonbuk, KR;
Han Sol Seo, Jeonbuk, KR;
Hyung Min Kim, Jeonbuk, KR;
YE Rang Kim, Jeonbuk, KR;
Dong Won Lee, Jeonbuk, KR;
Kyeong Yeol Seong, Jeonbuk, KR;
Han Sol Seo, Jeonbuk, KR;
Hyung Min Kim, Jeonbuk, KR;
Ye Rang Kim, Jeonbuk, KR;
Industrial Cooperation Foundation Chonbuk National University, Jeonju-Su, KR;
Abstract
The present invention relates to the preparation of poly(amino oxalate) (PAOX) using oxalyl chloride, 1,4-cyclohexanedimethanol, and piperazinediethanol, the preparation of biodegradable polymer particles using the PAOX, and the use of PAOX particles as a drug delivery vehicle. The PAOX according to the present invention is a polymer that has three characteristics of biodegradability, biocompatibility, and cationic properties at the same time with appropriate hydrophobicity and thus can be prepared as particles that allow rapid drug release. Moreover, the particles improve the delivery efficiency of a drug into cells and thus can be efficiently used as a drug delivery vehicle for the treatment of acute inflammatory diseases such as acute liver failure and acute lung injury.