The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2014

Filed:

Sep. 22, 2011
Applicants:

Abraham Nudelman, Rechovot, IL;

Ada Rephaeli, Herzlia, IL;

Irit Gil-ad, Herzlia, IL;

Abraham Weizman, Tel-Aviv, IL;

Mazal Shaul, Azur, IL;

Efrat Halbfinger, RaAnana, IL;

Inventors:

Abraham Nudelman, Rechovot, IL;

Ada Rephaeli, Herzlia, IL;

Irit Gil-Ad, Herzlia, IL;

Abraham Weizman, Tel-Aviv, IL;

Mazal Shaul, Azur, IL;

Efrat Halbfinger, RaAnana, IL;

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 37/30 (2006.01); A61K 31/205 (2006.01); C07C 57/02 (2006.01); C07C 57/18 (2006.01); C07C 231/00 (2006.01); C07C 237/06 (2006.01); C07C 57/15 (2006.01); C07C 231/12 (2006.01); C07C 231/02 (2006.01); C07C 51/41 (2006.01);
U.S. Cl.
CPC ...
C07C 57/15 (2013.01); C07C 237/06 (2013.01); C07B 2200/13 (2013.01); C07C 231/12 (2013.01); C07C 2103/32 (2013.01); C07C 231/02 (2013.01); C07C 51/412 (2013.01);
Abstract

An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.


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