The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2014

Filed:

May. 04, 2011
Applicants:

Mark Edward Bunnage, Concord, MA (US);

Andrew Simon Cook, Sandwich, GB;

Jingrong Jean Cui, San Diego, CA (US);

Kevin Nell Dack, Sandwich, GB;

Judith Gail Deal, San Diego, CA (US);

Danlin Gu, San Diego, CA (US);

Mingying He, San Diego, CA (US);

Patrick Stephen Johnson, Sandwich, GB;

Ted William Johnson, San Diego, CA (US);

Phuong Thi Quy Le, San Diego, CA (US);

Cynthia Louise Palmer, San Diego, CA (US);

Hong Shen, San Diego, CA (US);

Inventors:

Mark Edward Bunnage, Concord, MA (US);

Andrew Simon Cook, Sandwich, GB;

Jingrong Jean Cui, San Diego, CA (US);

Kevin Nell Dack, Sandwich, GB;

Judith Gail Deal, San Diego, CA (US);

Danlin Gu, San Diego, CA (US);

Mingying He, San Diego, CA (US);

Patrick Stephen Johnson, Sandwich, GB;

Ted William Johnson, San Diego, CA (US);

Phuong Thi Quy Le, San Diego, CA (US);

Cynthia Louise Palmer, San Diego, CA (US);

Hong Shen, San Diego, CA (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4427 (2006.01); C07D 213/73 (2006.01); C07D 498/04 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07F 9/53 (2006.01); C07D 471/04 (2006.01); C07D 403/04 (2006.01); C07D 417/04 (2006.01); C07D 403/12 (2006.01); C07F 9/6558 (2006.01); C07F 5/02 (2006.01); C07D 413/04 (2006.01); C07D 417/14 (2006.01); C07D 241/20 (2006.01); C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 451/02 (2006.01); C07D 401/04 (2006.01); C07F 7/18 (2006.01);
U.S. Cl.
CPC ...
C07D 213/73 (2013.01); C07D 498/04 (2013.01); C07D 413/14 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07F 9/5325 (2013.01); C07D 471/04 (2013.01); C07D 403/04 (2013.01); C07D 417/04 (2013.01); C07D 403/12 (2013.01); C07F 9/65583 (2013.01); C07F 5/025 (2013.01); C07D 413/04 (2013.01); C07D 417/14 (2013.01); C07D 241/20 (2013.01); C07D 401/14 (2013.01); C07D 401/12 (2013.01); C07D 451/02 (2013.01); C07D 401/04 (2013.01); C07F 7/1856 (2013.01);
Abstract

The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.


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