The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2014
Filed:
Jun. 24, 2014
Board of Regents, the University of Texas System, Austin, TX (US);
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Gaetano T. Montelione, Highland Park, NJ (US);
Kalyan Das, East Brunswick, NJ (US);
Edward Arnold, Belle Mead, NJ (US);
Li-Chung Ma, Princeton Junction, NJ (US);
Rong Xiao, Princeton, NJ (US);
Robert M. Krug, Austin, TX (US);
Karen Y. Twu, Fort Worth, TX (US);
Rei-Lin Kuo, Taipei, TW;
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.