The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2014
Filed:
Apr. 26, 2006
Hendrik Coenraad Hemker, Maastricht, NL;
Suzette Beguin, Villers-Agron, FR;
Raed Al-dieri, Maastricht, NL;
Robert Wagenvoord, Maastricht, NL;
Sebastiaan Nijhuis, Maastricht, NL;
Peter Giesen, Maastricht, NL;
Hendrik Coenraad Hemker, Maastricht, NL;
Suzette Beguin, Villers-Agron, FR;
Raed Al-Dieri, Maastricht, NL;
Robert Wagenvoord, Maastricht, NL;
Sebastiaan Nijhuis, Maastricht, NL;
Peter Giesen, Maastricht, NL;
Synapse B.V., Maastricht, NL;
Abstract
The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within a range of 0.05 to 5 mm and a surface within a range of 10 to 500 mm2; —allowing thrombin to generate in said sample; —measuring the fluorescence emitted from the surface of the layer, by the fluorescent group released from the fluorogenic substrate as a result of enzymatic action of generated thrombin on said fluorogenic substrate.