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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8916206 B1

PDFFull Text
Date of Patent:
Dec. 23, 2014

Filed:

Nov. 29, 2006

Nanoparticles containing water-soluble non-peptide low-molecular weight drug

Applicants:

Tsutomu Ishihara, Ohta-ku, JP;

Ayako Mizushima, Minato-ku, JP;

Inventors:

Tsutomu Ishihara, Ohta-ku, JP;

Yutaka Mizushima, Minato-ku, JP;

Assignee:

LTT Bio-Pharma Co., Ltd., Tokyo, JP;

Attorney:

Drinker Biddle & Reath LLP

Primary Examiner:

Aradhana Sasan

Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 31/19 (2006.01); A61K 31/56 (2006.01); A61K 9/51 (2006.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01); A61K 31/5575 (2006.01); A61K 33/24 (2006.01); A61K 33/26 (2006.01); A61K 33/30 (2006.01); A61K 33/32 (2006.01); A61K 33/34 (2006.01); A61K 45/06 (2006.01); A61K 47/34 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/19 (2013.01); A61K 9/5192 (2013.01); A61K 31/5575 (2013.01); A61K 31/56 (2013.01); A61K 33/24 (2013.01); A61K 33/26 (2013.01); A61K 33/30 (2013.01); A61K 33/32 (2013.01); A61K 33/34 (2013.01); A61K 45/06 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01);
Abstract

Drug-containing nanoparticles are provided that enable effective targeting and sustained-release of a water-soluble, non-peptide, low-molecular weight drug and cause reduced accumulation of the drug in the liver. The nanoparticles containing a water-soluble, non-peptide, low-molecular weight drug are obtained by hydrophobicizing the water-soluble, non-peptide, low-molecular weight drug by a metal ion, and reacting the hydrophobicized drug with a poly(lactic acid)-polyethylene glycol block copolymer or a poly(lactic-co-glycolic acid)-polyethylene glycol block copolymer. The nanoparticles have favorable targeting and sustained-release properties and cause reduced accumulation of the drug in the liver.

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