The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2014

Filed:

Mar. 13, 2013
Applicant:

Abraxis Bioscience, Llc, Los Angeles, CA (US);

Inventors:

Vuong Trieu, Agoura Hills, CA (US);

Neil P. Desai, Los Angeles, CA (US);

Patrick Soon-Shiong, Los Angeles, CA (US);

Assignee:

Abraxis BioSciences, LLC, Los Angeles, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/00 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); C12Q 1/68 (2006.01); A61K 38/38 (2006.01);
U.S. Cl.
CPC ...
A61K 38/38 (2013.01); G01N 33/574 (2013.01); C12Q 2600/106 (2013.01); C12Q 1/6886 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.


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