The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2014

Filed:

Oct. 05, 2007
Applicants:

Steven D. Axt, Menlo Park, CA (US);

Keshab Sarma, Sunnyvale, CA (US);

Justin Vitale, San Mateo, CA (US);

Jiang Zhu, Cupertino, CA (US);

Bruce Ross, Plainsboro, NJ (US);

Suguna Rachakonda, Robbinsville, NJ (US);

Quingwu Jin, San Jose, CA (US);

Byoung-kwon Chun, Robbinsville, NJ (US);

Inventors:

Steven D. Axt, Menlo Park, CA (US);

Keshab Sarma, Sunnyvale, CA (US);

Justin Vitale, San Mateo, CA (US);

Jiang Zhu, Cupertino, CA (US);

Bruce Ross, Plainsboro, NJ (US);

Suguna Rachakonda, Robbinsville, NJ (US);

Quingwu Jin, San Jose, CA (US);

Byoung-Kwon Chun, Robbinsville, NJ (US);

Assignee:

Gilead Pharmasset LLC, Foster City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 1/00 (2006.01); C07H 3/00 (2006.01); C08B 37/00 (2006.01); C07H 5/02 (2006.01); C07H 19/06 (2006.01);
U.S. Cl.
CPC ...
C07H 5/02 (2013.01); C07H 1/00 (2013.01); C07H 19/06 (2013.01);
Abstract

The present process provides an improved method for the preparation of 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase.


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