The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Sep. 12, 2011
Werngard Czechtizky, Frankfurt am Main, DE;
John Weston, Frankfurt am Main, DE;
Nils Rackelmann, Frankfurt am Main, DE;
Michael Podeschwa, Frankfurt am Main, DE;
Petra Arndt, Frankfurt am Main, DE;
Klaus Wirth, Frankfurt am Main, DE;
Heinz Goegelein, Frankfurt am Main, DE;
Olaf Ritzeler, Frankfurt am Main, DE;
Volker Kraft, Frankfurt am Main, DE;
Patrice Bellevergue, Paris, FR;
Gary Mccort, Paris, FR;
Werngard Czechtizky, Frankfurt am Main, DE;
John Weston, Frankfurt am Main, DE;
Nils Rackelmann, Frankfurt am Main, DE;
Michael Podeschwa, Frankfurt am Main, DE;
Petra Arndt, Frankfurt am Main, DE;
Klaus Wirth, Frankfurt am Main, DE;
Heinz Goegelein, Frankfurt am Main, DE;
Olaf Ritzeler, Frankfurt am Main, DE;
Volker Kraft, Frankfurt am Main, DE;
Patrice Bellevergue, Paris, FR;
Gary McCort, Paris, FR;
Sanofi, Paris, FR;
Abstract
The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.