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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8912199 B1

PDFFull Text
Date of Patent:
Dec. 16, 2014

Filed:

Oct. 21, 2013

Modulators of atp-binding cassette transporters

Applicant:

Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);

Inventors:

Sara S. Hadida Ruah, La Jolla, CA (US);

Peter D. J. Grootenhuis, San Diego, CA (US);

Fredrick Van Goor, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Brian Bear, Oceanside, CA (US);

Mark T. Miller, San Diego, CA (US);

Jason McCartney, Cardiff by the Sea, CA (US);

Mehdi Michel Jamel Numa, San Diego, CA (US);

Xiaoqing Yang, San Diego, CA (US);

Assignee:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Attorneys:

Honigman Miller Schwartz and Cohn LLP

Heidi Berven

Jonathan P. O'Brien

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/4523 (2006.01); A61K 31/4525 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4439 (2006.01); A61K 31/41 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/4192 (2006.01); A61K 31/404 (2006.01); C07D 471/04 (2006.01); C07D 405/12 (2006.01); G01N 33/50 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01); C07D 211/00 (2006.01); C07D 235/04 (2006.01); C07D 257/02 (2006.01); C07D 249/04 (2006.01); C07D 487/00 (2006.01); C07D 405/02 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5008 (2013.01); C07D 471/04 (2013.01); C07D 405/14 (2013.01); C07D 405/12 (2013.01); C07D 403/12 (2013.01);
Abstract

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

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