The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Sep. 16, 2011
Tracey C. Fleischer, Sandy, UT (US);
Daniel M. Cimbora, Salt Lake City, UT (US);
Jeffrey S. Flick, Salt Lake City, UT (US);
Andrew D. Gassman, Salt Lake City, UT (US);
Vijay R. Baichwal, Salt Lake City, UT (US);
Damon I. Papac, Mountain Brook, AL (US);
Tracey C. Fleischer, Sandy, UT (US);
Daniel M. Cimbora, Salt Lake City, UT (US);
Jeffrey S. Flick, Salt Lake City, UT (US);
Andrew D. Gassman, Salt Lake City, UT (US);
Vijay R. Baichwal, Salt Lake City, UT (US);
Damon I. Papac, Mountain Brook, AL (US);
Alzheimer's Institute of America, Inc., Kansas City, KS (US);
Abstract
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to therapeutic methods that utilize Nampt inhibitors in combination with NAD biosynthesis precursors to intentionally kill cancer cells while limiting or minimizing toxicity to normal host cells; and it relates to methods of identifying cancers that will be most responsive to treatment with Nampt inhibitors, particularly when administered in combination with nicotinic acid.