The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Nov. 16, 2011
Duan MA, Shanghai, CN;
Jingui Mu, Shanghai, CN;
Jiping Wang, Shanghai, CN;
Huijun Wang, Shanghai, CN;
Wang Liang, Shanghai, CN;
Duan Ma, Shanghai, CN;
Jingui Mu, Shanghai, CN;
Jiping Wang, Shanghai, CN;
Huijun Wang, Shanghai, CN;
Wang Liang, Shanghai, CN;
Fudan University, Shanghai, CN;
Abstract
The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.