The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Mar. 31, 2014
Applicant:
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Inventors:
Yulia A. Komarova, Chicago, IL (US);
Uzma Saqib, Chicago, IL (US);
Stephen M. Vogel, Chicago, IL (US);
Asrar B. Malik, Chicago, IL (US);
Assignee:
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); C07K 7/08 (2006.01); C07K 7/06 (2006.01); C07K 14/705 (2006.01); A61K 47/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48276 (2013.01); A61K 38/1709 (2013.01); A61K 38/00 (2013.01); C07K 7/08 (2013.01); C07K 7/06 (2013.01); C07K 2319/033 (2013.01); C07K 14/705 (2013.01); C07K 2319/10 (2013.01);
Abstract
Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for treating lung injury, including acute lung injury, which may include hyperpermeability of lung vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion.