The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Jul. 06, 2012
Marc Hubert Mercken, Beerse, BE;
Marianne Borgers, Balen, BE;
Marc Maria Pierre Pelagie Vandermeeren, Beerse, BE;
Bianca Julia J Van Broeck, Beerse, BE;
Marc Hubert Mercken, Beerse, BE;
Marianne Borgers, Balen, BE;
Marc Maria Pierre Pelagie Vandermeeren, Beerse, BE;
Bianca Julia J Van Broeck, Beerse, BE;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide fragments Aβ1-37, Aβ3-37, Aβ3p-37, Aβ1-37 and Aβ11p-37, and other like fragments ending at the 37amino acid of APP, hereinafter also referred to as the Aβx-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an Aβx-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of Aβx-37 peptides in a sample, such as a biological sample.