The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Oct. 24, 2011
Edward Boyden, Chestnut Hill, MA (US);
Jacob Bernstein, Cambridge, MA (US);
Christian Wentz, Cambridge, MA (US);
Giovanni Talei Franzesi, Boston, MA (US);
Michael Baratta, Boulder, CO (US);
Brian Allen, Cambridge, MA (US);
Anthony Zorzos, Cambridge, MA (US);
Jorg Scholvin, Boston, MA (US);
Clifton Fonstad, Arlington, MA (US);
Edward Boyden, Chestnut Hill, MA (US);
Jacob Bernstein, Cambridge, MA (US);
Christian Wentz, Cambridge, MA (US);
Giovanni Talei Franzesi, Boston, MA (US);
Michael Baratta, Boulder, CO (US);
Brian Allen, Cambridge, MA (US);
Anthony Zorzos, Cambridge, MA (US);
Jorg Scholvin, Boston, MA (US);
Clifton Fonstad, Arlington, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light.