The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 09, 2014

Filed:

Nov. 16, 2010
Applicants:

Daniel G. Stearns, Mountain View, CA (US);

Bradley W. Rice, Danville, CA (US);

Michael D. Cable, Danville, CA (US);

Inventors:

Daniel G. Stearns, Mountain View, CA (US);

Bradley W. Rice, Danville, CA (US);

Michael D. Cable, Danville, CA (US);

Assignee:

Xenogen Corporation, Alameda, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
H04N 13/02 (2006.01); G01B 11/24 (2006.01); G01N 21/76 (2006.01); A61K 49/00 (2006.01); G01N 21/64 (2006.01); G01B 11/25 (2006.01); G01B 9/02 (2006.01);
U.S. Cl.
CPC ...
G01N 21/763 (2013.01); A61K 49/0013 (2013.01); G01N 21/6456 (2013.01); G01B 11/24 (2013.01); G01B 11/2518 (2013.01); G01B 9/02004 (2013.01); G01B 9/02041 (2013.01); G01B 9/0203 (2013.01); H04N 13/0271 (2013.01); H04N 13/0203 (2013.01); H04N 13/025 (2013.01);
Abstract

The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.


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