The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Dec. 27, 2013
Nard Institute, Ltd., Amagasaki, JP;
Hidekazu Nakao, Amagasaki, JP;
Junichi Hoshino, Amagasaki, JP;
Tokutaro Ogata, Kobe, JP;
Naoki Miyashita, Amagasaki, JP;
Yoshikazu Yamamoto, Amagasaki, JP;
Nard Institute, Ltd., Amagasaki-Shi, Hyogo, JP;
Osaka University, Osaka, JP;
Abstract
The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MTreceptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein Ris a protective group of the amino group and the like; Ris a protective group of the carboxy group and the like; Ris a hydrogen atom and the like; Ris a halogen atom and the like; A is —(CH)—[Z(CH)]—; X is a leaving group.