The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 09, 2014

Filed:

Apr. 29, 2008
Applicants:

John A. Flygare, Burlingame, CA (US);

Frederick Cohen, San Francisco, CA (US);

Kurt Deshayes, San Francisco, CA (US);

Michael F. T. Koehler, Palo Alto, CA (US);

Lewis J. Gazzard, Belmont, CA (US);

Lan Wang, Foster City, CA (US);

Chudi Ndubaku, San Francisco, CA (US);

Inventors:

John A. Flygare, Burlingame, CA (US);

Frederick Cohen, San Francisco, CA (US);

Kurt Deshayes, San Francisco, CA (US);

Michael F. T. Koehler, Palo Alto, CA (US);

Lewis J. Gazzard, Belmont, CA (US);

Lan Wang, Foster City, CA (US);

Chudi Ndubaku, San Francisco, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 277/46 (2006.01); C07D 513/04 (2006.01); C07D 417/14 (2006.01); A61K 31/4365 (2006.01); A61K 31/4436 (2006.01); A61K 31/427 (2006.01); C07D 207/16 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); C07D 207/16 (2013.01); C07D 519/00 (2013.01);
Abstract

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1-M-U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3', R4, R4′ and R5, are as described herein.


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