The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Jul. 25, 2006
Ira H. Pastan, Potomac, MD (US);
Masanori Onda, Rockville, MD (US);
Satoshi Nagata, Sioux Falls, SD (US);
David Fitzgerald, Rockville, MD (US);
Robert Kreitman, Potomac, MD (US);
Byungkook Lee, Potomac, MD (US);
Ira H. Pastan, Potomac, MD (US);
Masanori Onda, Rockville, MD (US);
Satoshi Nagata, Sioux Falls, SD (US);
David Fitzgerald, Rockville, MD (US);
Robert Kreitman, Potomac, MD (US);
Byungkook Lee, Potomac, MD (US);
Abstract
The invention provides mutatedexotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.