The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Jun. 18, 2012
Sigrid DE Keersmaecker, Tienen, BE;
Dirk DE Vos, Holsbeek, BE;
Denis Ermolatev, Heverlee, BE;
Hans Steenackers, Waanrode, BE;
Erik Van Der Eycken, Ninove, BE;
Jozef Vanderleyden, Heverlee, BE;
Bharat S. Savaliya, Gujarat, IN;
Sigrid De Keersmaecker, Tienen, BE;
Dirk De Vos, Holsbeek, BE;
Denis Ermolatev, Heverlee, BE;
Hans Steenackers, Waanrode, BE;
Erik Van Der Eycken, Ninove, BE;
Jozef Vanderleyden, Heverlee, BE;
Bharat S. Savaliya, Gujarat, IN;
Katholieke Universiteit Leuven, K.U.Leuven R&D, Leuven, BE;
Abstract
The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.