The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Jul. 09, 2012
Applicants:
Iman El-hariry, Boston, MA (US);
David Proia, Newton, MA (US);
Vojo Vukovic, Winchester, MA (US);
Inventors:
Assignee:
Synta Pharmaceuticals Corp., Lexington, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); A61K 31/417 (2006.01); C07D 403/04 (2006.01); A61K 31/4196 (2006.01); A61K 45/06 (2006.01); A61K 31/4545 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/4196 (2013.01); A61K 45/06 (2013.01); A61K 31/4545 (2013.01); A61K 31/675 (2013.01); A61K 31/417 (2013.01);
Abstract
Methods of treating cancer with a compound of formulae (I) or (1a) are disclosed. Also provided are methods of treating a cancer with a mutation in ALK or a c-MET mutation with a compound of formulae (I) or (1a). Further provided are methods of treating non-small cell lung cancer with a mutation in ALK with a compound of formulae (I) or (1a); a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables structural formulae are defined herein.