The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 09, 2014

Filed:

Aug. 23, 2012
Applicants:

Romaan Raemaekers, De Pinte, BE;

Laurent Kubler, Beynost, FR;

Geert Karel Maria Plaetinck, Bottelare, BE;

Els Vanbleu, Berlare, BE;

Thierry Andre Olivier Eddy Bogaert, Kortrijk, BE;

Inventors:

Romaan Raemaekers, De Pinte, BE;

Laurent Kubler, Beynost, FR;

Geert Karel Maria Plaetinck, Bottelare, BE;

Els Vanbleu, Berlare, BE;

Thierry Andre Olivier Eddy Bogaert, Kortrijk, BE;

Assignee:

Devgen NV, Zwijnaarde, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.


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