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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8906852 B1

PDFFull Text
Date of Patent:
Dec. 09, 2014

Filed:

Apr. 08, 2011

Inhibitors of protein tyrosine kinase activity

Applicants:

Stéphane Raeppel, St. Lazare, CA;

Franck Raeppel, Montreal, CA;

Stephen William Claridge, Montreal, CA;

Lijie Zhan, Montreal, CA;

Frédéric Gaudette, Sherbrooke, CA;

Michael Mannion, Montreal, CA;

Norifumi Sato, Himeji, JP;

Yohei Yuki, Tokyo, JP;

Masashi Kishida, Ako, JP;

Arkadii Vaisburg, Kirkland, CA;

Inventors:

Stéphane Raeppel, St. Lazare, CA;

Franck Raeppel, Montreal, CA;

Stephen William Claridge, Montreal, CA;

Lijie Zhan, Montreal, CA;

Frédéric Gaudette, Sherbrooke, CA;

Michael Mannion, Montreal, CA;

Norifumi Sato, Himeji, JP;

Yohei Yuki, Tokyo, JP;

Masashi Kishida, Ako, JP;

Arkadii Vaisburg, Kirkland, CA;

Assignee:

MethylGene Inc., Montreal, CA;

Attorney:

Wood, Phillips, Katz, Clark & Mortimer

Primary Examiner:

Maury Audet

Assistant Examiner:

Zachary J Miknis

Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/47 (2006.01); A61P 35/00 (2006.01); C07K 14/515 (2006.01); A61P 9/10 (2006.01); A61P 27/02 (2006.01); A61K 38/05 (2006.01); A01N 57/00 (2006.01); A61K 31/675 (2006.01); A61K 31/535 (2006.01); A61K 31/497 (2006.01); A01N 43/42 (2006.01); A61K 31/44 (2006.01); C07F 9/06 (2006.01); C07F 9/28 (2006.01); C07D 513/02 (2006.01); C07D 495/04 (2006.01); C07F 9/6561 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); C07F 9/6561 (2013.01); A61K 38/005 (2013.01); C07D 519/00 (2013.01);
Abstract

This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.

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