The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Mar. 14, 2013
Applicant:
Institut Pasteur, Paris, FR;
Inventors:
Marie-Lise Gougeon, Clamart, FR;
Hela Saidi, Paris, FR;
Marie-Therese Melki, Paris, FR;
Beatrice Poirier-Beaudoin, Beynes, FR;
Valerie Seffer, Brunoy, FR;
Assignee:
Institut Pasteur, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/569 (2006.01); A61K 31/00 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56988 (2013.01); A61K 31/00 (2013.01); A61K 31/704 (2013.01); C12N 2740/16011 (2013.01); G01N 2333/16 (2013.01); G01N 2333/4703 (2013.01); G01N 2800/52 (2013.01);
Abstract
Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.