The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Jun. 23, 2011
Pharmaceutical composition in which solubility of partially soluble tricyclic derivative is improved
Myung-hwa Kim, Yongin-si, KR;
Kwang-woo Chun, Yongin-si, KR;
In-hae YE, Anyang-si, KR;
Jong-hee Choi, Suwon-si, KR;
Myung-Hwa Kim, Yongin-si, KR;
Kwang-Woo Chun, Yongin-si, KR;
In-Hae Ye, Anyang-si, KR;
Jong-Hee Choi, Suwon-si, KR;
Jeil Pharmaceutical Co., Ltd., Seoul, KR;
Abstract
A pharmaceutical composition includes lipid nanoparticles which include two or more of a phospholipid, cholesterol, and an ionic lipid, and a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. It is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.