The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2014
Filed:
Jun. 28, 2010
Rob Lavigne, Merksem, BE;
Stefan Miller, Regensburg, DE;
Yves Briers, Rohr AG, BE;
Guido Volckaert, Holsbeek, BE;
Maarten Walmagh, Herk-de-Stad, BE;
Rob Lavigne, Merksem, BE;
Stefan Miller, Regensburg, DE;
Yves Briers, Rohr AG, BE;
Guido Volckaert, Holsbeek, BE;
Maarten Walmagh, Herk-de-Stad, BE;
Lysando AG, Triesenberg, LI;
Katholieke Universiteit Leuven, K.U. Leuven R&D, Leuven, BE;
Abstract
The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions thereof. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors carrying the nucleic acid molecules and host cells transformed with either the nucleic acid molecules or the vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.