The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 02, 2014

Filed:

Jul. 02, 2009
Applicants:

Leslie Dakin, Waltham, MA (US);

James Edward Dowling, Waltham, MA (US);

Michelle Lamb, Waltham, MA (US);

Jon Read, Waltham, MA (US);

Xiaolan Zheng, Waltham, MA (US);

Inventors:

Leslie Dakin, Waltham, MA (US);

James Edward Dowling, Waltham, MA (US);

Michelle Lamb, Waltham, MA (US);

Jon Read, Waltham, MA (US);

Xiaolan Zheng, Waltham, MA (US);

Assignee:

AstraZeneca AB, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/10 (2006.01); A61K 31/454 (2006.01); C07D 417/14 (2006.01); A61K 31/427 (2006.01); C07D 277/34 (2006.01); C07D 417/06 (2006.01); A61K 31/426 (2006.01);
U.S. Cl.
CPC ...
C07D 417/10 (2013.01); C07D 417/14 (2013.01); A61K 31/427 (2013.01); C07D 277/34 (2013.01); C07D 417/06 (2013.01); A61K 31/426 (2013.01);
Abstract

The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.


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