The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2014
Filed:
May. 21, 2013
Teva Pharmaceuticals Australia Pty Ltd, Macquarie Park, AU;
Adam W. Clarke, Macquarie Park, AU;
Anthony G. Doyle, Macquarie Park, AU;
Philip A. Jennings, Macquarie Park, AU;
Norbert Kienzle, Macquarie Park, AU;
Matthew Pollard, Macquarie Park, AU;
Teva Pharmaceuticals Australia Pty Ltd, Macquarie Park, NSW, AU;
Abstract
The present invention provides humanised antibodies and binding domains thereof with anti-tumor activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.