The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2014
Filed:
Mar. 27, 2012
Jinyi Liu, Beijing, CN;
Xiaoxia Niu, Beijing, CN;
Minyi Zhou, Beijing, CN;
Yi Yang, Beijing, CN;
Jianbo Sun, Beijing, CN;
Yongqing Cheng, Beijing, CN;
Jinyi Liu, Beijing, CN;
Xiaoxia Niu, Beijing, CN;
Minyi Zhou, Beijing, CN;
Yi Yang, Beijing, CN;
Jianbo Sun, Beijing, CN;
Yongqing Cheng, Beijing, CN;
Beijing Tri-Prime Genetic Engineering Co., Ltd, Beijing, CN;
Beijing Bio-Tech Development Co., Ltd., Beijing, CN;
Abstract
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.